Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion
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چکیده
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The immune response against helminths and allergens is generally characterized by high levels of IgE and increased numbers of Th2 cells, eosinophils, and mast cells, yet the clinical outcome with respect to immediate hypersensitivity and inflammation is clearly not the same. High levels of IgE are seen to allergens during helminth infections; however, these IgE responses do not translate into a...
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Background Ofloxacin is a second-generation fluoroquinolone that frequently has been prescribed against various bacterial infections. Serious hypersensitivity reactions will increase with high worldwide consumption. There have been few case reports of ofloxacin induced anaphylaxis and its pathogenic mechanism is not well understood. In this study, we investigated pathogenic mechanisms in a 20-y...
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BACKGROUND Naturally occurring IgE-specific IgG autoantibodies have been identified in patients with asthma and other diseases, but their spectrum of functions is poorly understood. OBJECTIVE Address the hypothesis that: (i) IgG anti-IgE autoantibodies are detectable in the serum of all subjects but elevated in asthmatic patients regardless of atopic status as compared with controls; (ii) som...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1412663111